Nucleosome

complex

Nucleosome complexes released in neutrophil extracellular traps promote platelet activation and thrombus formation at the site of plaque rupture.

Pathway placement

Cascade stepPlatelet adhesion & activation

Confidencehigh

RationaleNET-associated marker; neutrophil extracellular trap component correlating with thrombotic burden.

Also acts inVascular inflammation

Druggability

Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-21.3

Confounder panel (Type-II drivers)

No confounder evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Plasma (citrate for coagulation complexes)

Collection tube

Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich ELISA against neo-complex epitope

Reagent / substrate

Antibody pair recognizing the assembled complex

Platform

ELISA plate

Turnaround · availability

Research / send-out · Research/specialized