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PAC-1
Pathway / Platelet adhesion & activation

PAC-1

protein

PAC-1 is a monoclonal antibody probe binding the activated (ligand-receptive) conformation of platelet integrin GPIIb-IIIa, directly reporting platelet activation and fibrinogen-receptor engagement.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationaleFlow-cytometry marker of GPIIb-IIIa activation; integrin conformational shift.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
75
C — confounder / Type-II
53
A — assay feasibility
68
E — evidence strength
28
T1DI (composite)
12
Specificity differential (R−C)+21.9
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(4)