Phosphatidylcholine 18:0
lipidPC18:0 activates platelet adhesion and aggregation during acute thrombotic events.
Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationaleLipid mediator promoting platelet activation in acute coronary syndrome.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only
Literature evidence(1)
- Acute coronary syndrome is associated with a substantial change in the platelet lipidome.Cardiovascular research · 2022 · PMID 34323932 · doi