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Phosphatidylserine
Pathway / Platelet adhesion & activation

Phosphatidylserine

lipid

Phosphatidylserine exposure on activated platelets and microparticles promotes platelet aggregation and thrombin generation.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencemedium
RationalePS externalization on platelets and microparticles drives coagulation and thrombotic activation.
Also acts inCoagulation / thrombus, Myocardial injury
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
76
A — assay feasibility
40
E — evidence strength
48
T1DI (composite)
4
Specificity differential (R−C)-61
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 3
2anemia / acute blood lossmag 3
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 3
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 1
7high-demand / peri-operative stressmag 2
Coverage: 7/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 21 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma (EDTA to limit oxidation)
Collection tube
K2/K3-EDTA (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
LC-MS/MS lipidomics (targeted or shotgun)
Reagent / substrate
Deuterated lipid-class internal standards; MS/MS transitions
Platform
LC-MS/MS
Turnaround · availability
Research · Research-only

Literature evidence(14)