Plasmin-α2-antiplasmin complex
complexPlasmin-α2-antiplasmin complex indicates active fibrinolysis and proteolytic thrombus remodeling during acute coronary occlusion.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleDirect marker of fibrinolytic activity and plasmin-mediated thrombus dissolution in acute MI.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized
Literature evidence(5)
- Perioperative cardiovascular complications rate and activity of coagulation and fibrinolysis among patients undergoing vascular surgery for peripheral artery disease and abdominal aortic aneurysm.Vascular · 2020 · PMID 32600160 · doi
- Thrombin activity throughout the acute phase of acute ST-elevation myocardial infarction and the relation to outcome.Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2009 · PMID 19552570 · doi
- Assessment of markers of thrombin generation in patients with acute myocardial infarction complicated by ventricular fibrillation.Clinical cardiology · 2006 · PMID 16649726 · doi
- Thrombogenesis in sickle cell disease.The Journal of laboratory and clinical medicine · 2001 · PMID 11385360 · doi
- Activation of coagulation and fibrinolysis after rehabilitative exercise in patients with coronary artery disease.The American journal of cardiology · 1998 · PMID 9527072 · doi