Plasmin-inhibitor complex
complexPlasmin-inhibitor complex marks active fibrinolysis and thrombus remodeling in myocardial infarction.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleMarker of active fibrinolysis; plasmin consumption indicates ongoing thrombus degradation.
Druggability
Not assessed (no mapped human gene target).
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I68
C — confounder / Type-II60
A — assay feasibility58
E — evidence strength27
T1DI (composite)9
Specificity differential (R−C)+8
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized
Literature evidence(2)
- [Predictive value of four items of new thrombus markers combined with conventional coagulation tests for thrombosis in antiphospholipid syndrome].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023 · PMID 38101785 · doi
- Relationship between intracoronary thrombolysis and fibrino-coagulation--special reference to TAT/PIC and FPA/PIC.Japanese circulation journal · 1996 · PMID 8741240 · doi