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Platelet-derived microparticles
Pathway / Platelet adhesion & activation

Platelet-derived microparticles

complex

Platelet-derived vesicles released during platelet activation that propagate tissue-factor-driven thrombus formation.

Pathway placement
Cascade stepPlatelet adhesion & activation
Confidencehigh
RationalePlatelet activation marker; triggers coagulation cascade; thrombotic driver in ACS.
Also acts inCoagulation / thrombus
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
71
C — confounder / Type-II
52
A — assay feasibility
58
E — evidence strength
27
T1DI (composite)
9
Specificity differential (R−C)+19.5
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized

Literature evidence(4)