Platelet glycoprotein Ib/V/IX complex

complex

GPIb/V/IX mediates the initial catch-bond interaction between platelets and von Willebrand factor at sites of endothelial injury.

Pathway placement

Cascade stepPlatelet adhesion & activation

Confidencehigh

RationalePrimary vWF-binding receptor; initial platelet adhesion to exposed subendothelium.

Also acts inEndothelial activation/erosion

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Plasma (citrate for coagulation complexes)

Collection tube

Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich ELISA against neo-complex epitope

Reagent / substrate

Antibody pair recognizing the assembled complex

Platform

ELISA plate

Turnaround · availability

Research / send-out · Research/specialized