Protein C activation peptide
peptidePeptide released during activated Protein C generation, marking endogenous anticoagulant pathway engagement.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencemedium
RationaleMarker of anticoagulant activation; coagulation system engagement in thrombosis.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade
Literature evidence(1)
- Assessment of hypercoagulable states by measurement of activation fragments and peptides.Blood reviews · 1990 · PMID 2182146 · doi