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Prothrombin fragment F1+2
Pathway / Coagulation & thrombus formation

Prothrombin fragment F1+2

peptide

F1+2 is released during prothrombin activation, quantifying thrombin generation and thrombotic activity in acute MI.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleDirect marker of thrombin generation and prothrombin activation in coagulation cascade.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
72
C — confounder / Type-II
59
A — assay feasibility
66
E — evidence strength
28
T1DI (composite)
11
Specificity differential (R−C)+13.6
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Literature evidence(7)