CoronaryAtlas logo
CoronaryAtlas
Thrombin
Pathway / Coagulation & thrombus formation

Thrombin

protein

Thrombin is generated by tissue-factor-triggered coagulation and drives fibrin polymerization and platelet activation in coronary thrombosis.

Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaleThrombin is the central coagulation protease; driver of fibrin formation in arterial thrombosis.
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
75
A — assay feasibility
68
E — evidence strength
42
T1DI (composite)
6
Specificity differential (R−C)-60
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 3
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressn/a
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 12 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(25)

Clinical trials(1)