Tissue Plasminogen Activator / Plasminogen Activator Inhibitor-1 Ratio
complexThe tPA/PAI-1 ratio quantifies net fibrinolytic activity; low ratio signals impaired thrombus lysis and predicts worse reperfusion in acute MI.
Pathway placement
Cascade stepCoagulation & thrombus formation
Confidencehigh
RationaletPA/PAI-1 ratio directly predicts fibrinolytic capacity and microvascular reperfusion.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (citrate for coagulation complexes)
Collection tube
Sodium citrate 3.2% (light blue-top) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich ELISA against neo-complex epitope
Reagent / substrate
Antibody pair recognizing the assembled complex
Platform
ELISA plate
Turnaround · availability
Research / send-out · Research/specialized
Literature evidence(1)
- Coagulation Markers and Myocardial Blush Grade in STEMI: Identifying Potential Predictors of Microvascular Reperfusion.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2026 · PMID 41549721 · doi