Angiotensin-Converting Enzyme
ACEproteinACE generates angiotensin II, promoting endothelial dysfunction, vascular inflammation, and pro-thrombotic state in coronary atherosclerosis.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleACE drives angiotensin-II production; endothelial dysfunction and inflammation via renin–angiotensin system.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates24
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000159640
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Human genetic evidence
0.612
Open Targets association (myocardial_infarction)
Literature evidence(5)
- Pathological cardiac remodeling seen by the eyes of proteomics.Biochimica et biophysica acta. Proteins and proteomics · 2021 · PMID 33607275 · doi
- Anti-inflammatory, Antithrombotic and Cardiac Remodeling Preventive Effects of Eugenol in Isoproterenol-Induced Myocardial Infarction in Wistar Rat.Cardiovascular toxicology · 2016 · PMID 26391896 · doi
- Insight into the mode of action of ACE inhibition in coronary artery disease: the ultimate 'EUROPA' story.Drugs · 2009 · PMID 19275271 · doi
- The role of inflammatory stress in acute coronary syndrome.Chinese medical journal · 2004 · PMID 14733789
- Useful laboratory tests for studying thrombogenesis in acute cardiac syndromes.Clinical chemistry · 1998 · PMID 9702994
Clinical trials(1)
- Comprehensive Treatment of Angina in Women With Microvascular Dysfunction - a Proof of Concept Study of the iPower CohortNCT02910154 · NA · COMPLETED · Diet, Training, Medication (with statin and ACE-inhibition)