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ATP Citrate Lyase
Pathway / Plaque inflammation

ATP Citrate Lyase

ACLYgene

ATP citrate lyase controls macrophage acetyl-CoA pools and lipid biosynthesis, influencing the pro-inflammatory versus stabilizing macrophage phenotype in atherosclerotic plaques.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleACLY regulates macrophage lipid metabolism and acetyl-CoA availability; affects plaque inflammatory state and stabilization.
Also acts inLipid entry/oxidation
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000131473

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
23
C — non-Type-I
57
A — assay feasibility
52
E — evidence strength
21
T1DI (composite)
4
Specificity differential (R−C)-33.9
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)