CoronaryAtlas logo
CoronaryAtlas
Tartrate-Resistant Acid Phosphatase
Pathway / Off-pathway / systemic markers

Tartrate-Resistant Acid Phosphatase

ACP5protein

TRAP reflects osteoclast activity and systemic bone metabolism but is not a direct atherothrombotic cascade mediator.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleBone-resorption marker; off atherothrombotic cascade.
Also acts inCap degradation / rupture, Vascular inflammation
Druggability
Not assessed (no mapped human gene target).

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
39
C — confounder / Type-II
70
A — assay feasibility
68
E — evidence strength
26
T1DI (composite)
6
Specificity differential (R−C)-31
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(2)