Acyl-CoA synthetase long-chain family member 1

ACSL1gene

ACSL1 overexpression in macrophages drives lipid uptake and esterification, promoting foam-cell formation and plaque destabilization.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencehigh

RationaleAMI biomarker candidate; rewires macrophage lipid metabolism driving foam-cell formation and plaque inflammation.

Also acts inVascular inflammation

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000151726

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable