ADH1B

ADH1Bgene

ADH1B variants influence alcohol-dependent lipid metabolism and systemic inflammation, modulating cardiovascular disease risk.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencemedium

RationaleAlcohol dehydrogenase 1B; alcohol metabolism enzyme; CAD association likely mediated via lipid and inflammatory pathways.

Also acts inLipid entry/oxidation

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable