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Midregional Pro-Adrenomedullin
Pathway / Off-pathway / systemic markers

Midregional Pro-Adrenomedullin

ADMpeptide

MR-proADM reflects endothelial dysfunction, hemodynamic stress, and renal complications; predicts MI and heart failure outcomes.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleEndothelial protection; hemodynamic/renal stress marker; prognostic predictor.
Also acts inEndothelial activation/erosion
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000148926

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
56
A — assay feasibility
66
E — evidence strength
50
T1DI (composite)
6
Specificity differential (R−C)-64.6
Direct evidence: higher in non-Type I (D=-2)
T2MI 0.97 (0.67-1.51) pmol/L vs T1MI 0.72 (0.53-0.99) pmol/L; P<.001
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencymag 1
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 2
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosisn/a
5CABG-relatedmag 2
Coverage: 3/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 6 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Plasma (EDTA; peptidase-labile — chilled + protease inhibitor)
Collection tube
K2-EDTA, chilled plastic (lavender-top) · Serum separator (gold/red-top, SST)
Method / principle
Competitive/sandwich immunoassay or LC-MS/MS
Reagent / substrate
Anti-peptide antibody; or isotope-labeled internal standard (MS)
Platform
Immunoassay / LC-MS/MS
Turnaround · availability
Send-out / research · Research-grade

Literature evidence(9)