ADRA1A

ADRA1Agene

ADRA1A-mediated α1-adrenergic signaling provides cardioprotection against myocardial ischemic injury.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencemedium

RationaleCardioprotection mechanism; off-cascade neuroendocrine/hemodynamic axis.

Druggability

DruggableYes

Known drugs / candidates66

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000120907

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

0.609

Open Targets association (myocardial_infarction)