Adrenergic receptor alpha-1D
ADRA1DgeneAlpha-1D adrenergic signaling contributes to vasoconstriction, hypertension, and adverse cardiac remodeling in response to chronic stress.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencehigh
RationaleAdrenergic signaling; vascular tone and cardiac remodeling.
Druggability
DruggableYes
Known drugs / candidates59
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000171873
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.604
Open Targets association (myocardial_infarction)
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.