Pathway / Off-pathway / systemic markers

Angiotensin II receptor type 1

AGTR1gene

AGTR1 mediates angiotensin II vasoconstriction and aldosterone secretion; central to hypertension, vascular inflammation, and thrombotic risk.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencehigh

RationaleNeurohormonal; blood pressure and vascular remodeling.

Druggability

DruggableYes

Known drugs / candidates24

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000144891

Type I vs Type II discrimination

ScoresShared / rises in both

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)+5.6

Confounder panel (Type-II drivers)

1sepsis / systemic inflammationmag 2

2anemia / acute blood lossn/a

3hypovolemia / dehydrationmag 2

4tachyarrhythmiamag 2

5hypoxemia / respiratory failuremag 2

6hypertensive emergencymag 2

7high-demand / peri-operative stressmag 1

Coverage: 6/7 confounders with evidence

Tier: deep-scored (abstract-extracted) · 19 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

0.617

Open Targets association (myocardial_infarction)

Literature evidence(0)

No direct literature mentions harvested; included via genetic/target evidence.