ALKBH1

ALKBH1gene

ALKBH1-mediated m6A demethylation regulates inflammatory cytokine and matrix-metalloproteinase expression, influencing plaque inflammation and fibrous-cap stability.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

Rationalem6A demethylation modulates inflammatory gene expression and matrix remodeling.

Also acts inCap degradation / rupture

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableNo

EnsemblENSG00000100601

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

Association of N-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts.
Cell death & disease · 2019 · PMID 31797919 · doi