Apolipoprotein A-I

Type I vs Type II discrimination

Assay & specimen

Literature evidence(30)

• Comprehensive Quality Analysis of Conventional and Novel Biomarkers in Diagnosing and Predicting Prognosis of Coronary Artery Disease, Acute Coronary Syndrome, and Heart Failure, a Comprehensive Literature Review.
  Journal of cardiovascular translational research · 2024 · PMID 38995611 · doi
• Quality Assurance for Multiplex Quantitative Clinical Chemistry Proteomics in Large Clinical Trials.
  The journal of applied laboratory medicine · 2024 · PMID 39239905 · doi
• Untargeted lipidomics reveals novel HDL metabotypes and lipid-clinical correlates.
  Journal of lipid research · 2024 · PMID 39490932 · doi
• Plasma Interleukin-6 (IL-6), Angiopoietin-2, and C-Reactive Protein Levels Predict Subsequent Type 1 Myocardial Infarction in Persons With Treated HIV Infection.
  Journal of acquired immune deficiency syndromes (1999) · 2023 · PMID 37018921 · doi
• Quartet of APOCs and the Different Roles They Play in Diabetes.
  Arteriosclerosis, thrombosis, and vascular biology · 2023 · PMID 37226733 · doi
• Prognostic significance of metabolomic biomarkers in patients with diabetes mellitus and coronary artery disease.
  Cardiovascular diabetology · 2022 · PMID 35525960 · doi
• Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study.
  eLife · 2022 · PMID 35535496 · doi
• Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.
  International journal of molecular sciences · 2022 · PMID 35683019 · doi
• Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction.
  Journal of cardiovascular translational research · 2022 · PMID 36197585 · doi
• High-Density Lipoprotein in Lupus: Disease Biomarkers and Potential Therapeutic Strategy.
  Arthritis & rheumatology (Hoboken, N.J.) · 2019 · PMID 31350818 · doi
• Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells.
  International journal of molecular sciences · 2019 · PMID 31382484 · doi
• Desmocollin 1 is abundantly expressed in atherosclerosis and impairs high-density lipoprotein biogenesis.
  European heart journal · 2018 · PMID 29106519 · doi
• Screening and Identification of Pregnancy Zone Protein and Leucine-Rich Alpha-2-Glycoprotein as Potential Serum Biomarkers for Early-Onset Myocardial Infarction using Protein Profile Analysis.
  Proteomics. Clinical applications · 2018 · PMID 30411527 · doi
• Oxidized lipoprotein lipids and atherosclerosis.
  Free radical research · 2017 · PMID 28412863 · doi
• ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease.
  Laboratory investigation; a journal of technical methods and pathology · 2016 · PMID 27183204 · doi
• Clinically significant novel biomarkers for prediction of first ever myocardial infarction: the Tromsø Study.
  Circulation. Cardiovascular genetics · 2015 · PMID 25613532 · doi
• The human HDL proteome displays high inter-individual variability and is altered dynamically in response to angioplasty-induced atheroma plaque rupture.
  Journal of proteomics · 2014 · PMID 24747125 · doi
• Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates.
  Journal of proteome research · 2014 · PMID 25345801 · doi
• Elevated plasma albumin and apolipoprotein A-I oxidation under suboptimal specimen storage conditions.
  Molecular & cellular proteomics : MCP · 2014 · PMID 24736286 · doi
• The metabolic and pharmacologic bases for treating atherogenic dyslipidaemia.
  Best practice & research. Clinical endocrinology & metabolism · 2013 · PMID 24840265 · doi
• Extended-release niacin/laropiprant improves endothelial function in patients after myocardial infarction.
  Heart and vessels · 2013 · PMID 23712600 · doi
• Integrated proteomic and metabolomic analysis reveals the NADH-mediated TCA cycle and energy metabolism disorders based on a new model of chronic progressive heart failure.
  Molecular bioSystems · 2013 · PMID 24108264 · doi
• Lipid disorders and their relevance to outcomes in chronic kidney disease.
  Blood purification · 2011 · PMID 21228589 · doi
• Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: a mechanistic link between local and systemic inflammation.
  Pharmacological research · 2011 · PMID 21771657 · doi
• Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities.
  Current opinion in lipidology · 2010 · PMID 20581677 · doi
• [Front line of oxidized lipoproteins: role of oxidized lipoproteins in atherogenesis and cardiovascular disease risk].
  Rinsho byori. The Japanese journal of clinical pathology · 2010 · PMID 20662275
• Lipid and lipoprotein profile in women with polycystic ovary syndrome.
  Canadian journal of physiology and pharmacology · 2008 · PMID 18418429 · doi
• The apoB/apoA-I ratio: a strong, new risk factor for cardiovascular disease and a target for lipid-lowering therapy--a review of the evidence.
  Journal of internal medicine · 2006 · PMID 16629855 · doi
• Pharmacologic augmentation of high-density lipoproteins: mechanisms of currently available and emerging therapies.
  Current opinion in cardiology · 2005 · PMID 15956828 · doi
• Proteomic analysis of plasma from patients during an acute coronary syndrome.
  Journal of the American College of Cardiology · 2004 · PMID 15489088 · doi

Clinical trials(1)

• A Phase 3, Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group Study to Investigate the Efficacy and Safety of CSL112 in Subjects With Acute Coronary Syndrome
  NCT03473223 · PHASE3 · COMPLETED · Apolipoprotein A-I [human] (apoA-I), Placebo