Apolipoprotein C-IV
APOC4proteinAPOC4 regulates lipoprotein metabolism and lipid composition; decreased levels may reflect altered lipid handling during acute MI.
Pathway placement
Cascade stepLipid retention & oxidation
Confidencelow
RationaleApolipoprotein; lipid-metabolism regulator; decreased in incident AMI.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000267467
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)
Literature evidence(1)
- A Mass Spectrometry-Based Proteome Study of Twin Pairs Discordant for Incident Acute Myocardial Infarction within Three Years after Blood Sampling Suggests Novel Biomarkers.International journal of molecular sciences · 2024 · PMID 38473885 · doi