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Apolipoprotein E
Pathway / Lipid retention & oxidation

Apolipoprotein E

APOEprotein

Apolipoprotein E is a lipoprotein structural protein and receptor ligand whose genetic polymorphisms influence LDL metabolism, lipoprotein retention, and atherosclerosis progression and MI susceptibility.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleLipoprotein structural component; genetic variants (ε2/ε3/ε4) influence lipid metabolism and atherosclerosis susceptibility.
Also acts inSystemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000130203

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
68
E — evidence strength
55
T1DI (composite)
5
Specificity differential (R−C)-75.7
Direct evidence: higher in Type II (D=-2)
APOE levels measured in type-2 AMI patients; comparative analysis of STEMI, NSTEMI, and type-2 AMI groups performed
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationn/a
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressn/a
Coverage: 2/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 3 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Human genetic evidence

0.589
Open Targets association (myocardial_infarction)
8
GWAS associations
Traits: myocardial infarction

Literature evidence(26)

Omics datasets(1)