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Apolipoprotein L1
Pathway / Myocardial injury (shared endpoint)

Apolipoprotein L1

APOL1protein

Apolipoprotein L1 phosphorylation accompanies acute myocardial injury and inversely correlates with troponin release.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationalePhosphorylated in AMI; inverse troponin correlation indicates myocardial injury.
Also acts inLipid entry/oxidation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000100342

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
30
C — non-Type-I
61
A — assay feasibility
68
E — evidence strength
23
T1DI (composite)
6
Specificity differential (R−C)-30.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)