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ATPase Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2
Pathway / Myocardial injury (shared endpoint)

ATPase Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2

ATP2A2gene

ATP2A2 phosphorylation dysregulates calcium homeostasis in ischemic cardiomyocytes following Type 1 MI.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleCalcium-handling protein phosphorylation reflects cardiomyocyte dysfunction post-MI.
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000174437

Type I vs Type II discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — confounder / Type-II
67
A — assay feasibility
52
E — evidence strength
86
T1DI (composite)
22
Specificity differential (R−C)0
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationmag 2
4tachyarrhythmiamag 2
5hypoxemia / respiratory failuremag 2
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 2
Coverage: 6/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 14 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

1
GWAS associations
Traits: myocardial infarction

Literature evidence(1)