Pathway / Myocardial injury (shared endpoint)

ATPase Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase 2

ATP2A2gene

ATP2A2 phosphorylation dysregulates calcium homeostasis in ischemic cardiomyocytes following Type 1 MI.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleCalcium-handling protein phosphorylation reflects cardiomyocyte dysfunction post-MI.

Druggability

DruggableYes

Known drugs / candidates2

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000174437

Type I vs non-Type I discrimination

ScoresShared / rises in both

R — rupture / Type-I

C — non-Type-I

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)+4.8

Non-Type-I axis panel

Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.

2sepsis / systemic inflammationmag 2

2anemia / acute blood lossmag 2

2hypovolemia / dehydrationmag 2

2tachyarrhythmiamag 2

2hypoxemia / respiratory failuremag 2

2hypertensive emergencyn/a

2high-demand / peri-operative stressmag 2

3sudden cardiac deathmag 1

4aPCI-related periproceduraln/a

4bstent thrombosisn/a

4cin-stent restenosisn/a

5CABG-relatedn/a

Coverage: 7/12 axes with evidence

Tier: deep-scored (abstract-extracted) · 13 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Human genetic evidence

GWAS associations

Traits: myocardial infarction

Literature evidence(1)

Comparative Proteomic and Phosphoproteomic Analyses Reveal Molecular Signatures of Myocardial Infarction and Transverse Aortic Constriction in Aged Mouse Models.
Cardiology research and practice · 2024 · PMID 39502510 · doi