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Complement Component 4B
Pathway / Plaque inflammation

Complement Component 4B

C4Bprotein

C4B complement cascade activation recruits inflammatory cells to destabilize atherosclerotic plaques.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleComplement activation drives monocyte recruitment and plaque inflammation in atherosclerosis.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000224389

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
73
C — non-Type-I
66
A — assay feasibility
68
E — evidence strength
31
T1DI (composite)
11
Specificity differential (R−C)+7
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)