Complement Component 4B

C4Bprotein

C4B complement cascade activation recruits inflammatory cells to destabilize atherosclerotic plaques.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleComplement activation drives monocyte recruitment and plaque inflammation in atherosclerosis.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000224389

Type I vs Type II discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)+2.5

Confounder panel (Type-II drivers)

No confounder evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)