Complement C8B

C8Bprotein

C8B, part of the complement membrane-attack complex, participates in plaque inflammation and vascular injury during acute coronary syndrome.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleComplement activation contributes to plaque inflammation and endothelial activation.

Also acts inSystemic / off-pathway

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000021852

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)