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Procalcitonin
Pathway / Off-pathway / systemic markers

Procalcitonin

CALCApeptide

Procalcitonin is a systemic inflammatory marker elevated in MI-associated infection and ischemic stress, off the atherothrombotic cascade.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencemedium
RationaleSystemic inflammatory biomarker; non-plaque-specific acute-phase response in MI.
Also acts inVascular inflammation
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000110680

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
63
A — assay feasibility
96
E — evidence strength
49
T1DI (composite)
10
Specificity differential (R−C)-59.5
Direct evidence: higher in non-Type I (D=-1)
T2MI had higher baseline procalcitonin than T1MI (direction reported; magnitude/p-value not given in abstract)
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 3
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressmag 1
3sudden cardiac deathmag 2
4aPCI-related periproceduralmag 1
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 8/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 21 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Chemiluminescent sandwich immunoassay
Reagent / substrate
Anti-PCT antibody pair (BRAHMS)
Platform
Automated; POC
Turnaround · availability
Rapid · FDA-cleared

Literature evidence(3)