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Caspase-1
Pathway / Plaque inflammation

Caspase-1

CASP1protein

Caspase-1 activates pro-inflammatory cytokines IL-1β and IL-18 via the NLRP3 inflammasome, promoting plaque inflammation and destabilization.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleNLRP3 inflammasome component that releases IL-1β and IL-18; drives plaque inflammation and destabilization in atherosclerosis.
Druggability
DruggableYes
Known drugs / candidates3
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000137752

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
0
C — non-Type-I
60
A — assay feasibility
72
E — evidence strength
55
T1DI (composite)
8
Specificity differential (R−C)-60
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 2
2hypovolemia / dehydrationmag 2
2tachyarrhythmiamag 2
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressmag 1
3sudden cardiac deathmag 1
4aPCI-related periproceduralmag 2
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 10/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 33 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(7)