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CAT
Pathway / Lipid retention & oxidation

CAT

CATgene

CAT dysregulation impairs hydrogen-peroxide clearance, allowing lipid-driven oxidative stress to amplify atherosclerotic lesion progression.

Pathway placement
Cascade stepLipid retention & oxidation
Confidencemedium
RationaleCatalase dysregulated in atherosclerosis; antioxidant enzyme controlling oxidative stress from retained, modified lipids.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000121691

Type I vs non-Type I discrimination

ScoresIndeterminate
R — rupture / Type-I
—
C — non-Type-I
33
A — assay feasibility
52
E — evidence strength
—
T1DI (composite)
—
Specificity differential (R−C)-18.3
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuren/a
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathn/a
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosismag 1
5CABG-relatedmag 1
Coverage: 2/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 3 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(2)