CBFA2/RUNX1 Partner Transcriptional Co-repressor 3
CBFA2T3geneCBFA2T3 is a CAD-associated super-enhancer-regulated gene whose role in atherothrombotic MI likely involves cell-type-specific transcriptional control.
Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleSuper-enhancer-regulated CAD gene; transcriptional regulation mechanism; off-pathway regulatory locus.
Druggability
Not assessed (no mapped human gene target).
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Integrative functional analysis of super enhancer SNPs for coronary artery disease.Journal of human genetics · 2018 · PMID 29491472 · doi