CoronaryAtlas logo
CoronaryAtlas
CBLB
Pathway / Plaque inflammation

CBLB

CBLBgene

CBLB regulates acute myocardial infarction through immune cell activation and metabolic responses affecting plaque inflammation and systemic metabolic stress.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleRegulates immune and metabolic pathways in AMI.
Also acts inLipid entry/oxidation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000114423

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
20
C — confounder / Type-II
41
A — assay feasibility
52
E — evidence strength
16
T1DI (composite)
3
Specificity differential (R−C)-20.9
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)