CoronaryAtlas logo
CoronaryAtlas
CD40
Pathway / Plaque inflammation

CD40

CD40gene

CD40–CD40L interaction promotes endothelial activation, leukocyte recruitment, and platelet–leukocyte thromboinflammatory crosstalk.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleInflammatory signaling receptor on endothelial and immune cells; leukocyte-platelet interaction mediator.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates10
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000101017

Type I vs non-Type I discrimination

ScoresShared / rises in both
R — rupture / Type-I
67
C — non-Type-I
54
A — assay feasibility
52
E — evidence strength
42
T1DI (composite)
12
Specificity differential (R−C)+12.5
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 2
2hypovolemia / dehydrationn/a
2tachyarrhythmiamag 1
2hypoxemia / respiratory failuremag 1
2hypertensive emergencyn/a
2high-demand / peri-operative stressmag 1
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 2
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 8/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 17 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(10)