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CD40
Pathway / Plaque inflammation

CD40

CD40gene

CD40–CD40L interaction promotes endothelial activation, leukocyte recruitment, and platelet–leukocyte thromboinflammatory crosstalk.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleInflammatory signaling receptor on endothelial and immune cells; leukocyte-platelet interaction mediator.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates10
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000101017

Type I vs Type II discrimination

ScoresIndeterminate
R — rupture / Type-I
67
C — confounder / Type-II
47
A — assay feasibility
52
E — evidence strength
42
T1DI (composite)
13
Specificity differential (R−C)+20
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossmag 2
3hypovolemia / dehydrationn/a
4tachyarrhythmiamag 1
5hypoxemia / respiratory failuremag 1
6hypertensive emergencyn/a
7high-demand / peri-operative stressmag 1
Coverage: 5/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 12 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(10)