CoronaryAtlas logo
CoronaryAtlas
Vascular Endothelial Cadherin
Pathway / Endothelial activation & erosion

Vascular Endothelial Cadherin

CDH5protein

Vascular endothelial cadherin cleavage destabilizes endothelial junctions, enabling transmigration and exposing subendothelial matrix.

Pathway placement
Cascade stepEndothelial activation & erosion
Confidencehigh
RationaleVE-cadherin maintains endothelial barrier integrity; degradation is hallmark of endothelial erosion and leukocyte transmigration.
Also acts inMyocardial injury, Vascular inflammation, Coagulation / thrombus
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000179776

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
47
C — confounder / Type-II
74
A — assay feasibility
68
E — evidence strength
28
T1DI (composite)
7
Specificity differential (R−C)-26.3
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(11)