Cyclin-Dependent Kinase 7

CDK7gene

CDK7 regulates inflammatory gene expression and cell proliferation in plaque-resident immune and vascular cells.

Pathway placement

Cascade stepPlaque inflammation

Confidencemedium

RationaleCell-cycle and transcriptional regulator implicated in plaque inflammatory progression.

Also acts inCap degradation / rupture

Druggability

DruggableYes

Known drugs / candidates9

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000134058

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable