CLEC4E

CLEC4Egene

CLEC4E promotes monocyte and macrophage recruitment and activation in atherosclerotic plaques, driving inflammation and rupture susceptibility.

Pathway placement

Cascade stepPlaque inflammation

Confidencehigh

RationaleC-type lectin domain family 4 member E; myeloid C-type lectin driving innate immune recognition and myeloid activation.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableYes

EnsemblENSG00000166523

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable