Collagen type I alpha-2 chain
COL1A2geneCOL1A2 is the predominant fibrillar collagen dysregulated in post-MI fibrotic remodeling.
Pathway placement
Cascade stepFibrous-cap degradation & rupture
Confidencehigh
RationaleMajor extracellular matrix protein; post-MI fibrosis and macrophage dysregulation.
Also acts inMyocardial injury
Druggability
DruggableYes
Known drugs / candidates2
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000164692
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I26
C — confounder / Type-II59
A — assay feasibility52
E — evidence strength22
T1DI (composite)4
Specificity differential (R−C)-33.1
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(2)
- Persistent transcriptional changes in cardiac adaptive immune cells following myocardial infarction: New evidence from the re-analysis of publicly available single cell and nuclei RNA-sequencing data sets.Journal of molecular and cellular cardiology · 2024 · PMID 38734060 · doi
- A combined analysis of bulk RNA-seq and scRNA-seq was performed to investigate the molecular mechanisms associated with the occurrence of myocardial infarction.BMC genomics · 2024 · PMID 39363266 · doi