CPEB1
CPEB1geneCPEB1 controls endothelial cell apoptosis and inflammatory pathways contributing to endothelial erosion.
Pathway placement
Cascade stepEndothelial activation & erosion
Confidencemedium
RationaleRegulates endothelial apoptosis and inflammatory signaling; links to endothelial activation.
Also acts inVascular inflammation
Druggability
DruggableNo
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableNo
EnsemblENSG00000214575
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Literature evidence(1)
- Depletion of CPEB1 protects against oxidized LDL-induced endothelial apoptosis and inflammation though SIRT1/LOX-1 signalling pathway.Life sciences · 2019 · PMID 31521690 · doi