CoronaryAtlas logo
CoronaryAtlas
C-reactive protein
Pathway / Plaque inflammation

C-reactive protein

CRPprotein

hs-CRP is a systemic inflammatory marker reflecting plaque-driven inflammation and predicting atherothrombotic events.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleAnchor molecule; acute-phase inflammatory marker in plaque destabilization.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000132693

Type I vs Type II discrimination

ScoresType-II-associated
R — rupture / Type-I
—
C — confounder / Type-II
67
A — assay feasibility
96
E — evidence strength
49
T1DI (composite)
11
Specificity differential (R−C)-52
Confounder panel (Type-II drivers)
1sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
3hypovolemia / dehydrationmag 2
4tachyarrhythmian/a
5hypoxemia / respiratory failuremag 2
6hypertensive emergencymag 2
7high-demand / peri-operative stressn/a
Coverage: 4/7 confounders with evidence
Tier: deep-scored (abstract-extracted) · 7 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Immunoturbidimetric or immunonephelometric (latex-enhanced for hs)
Reagent / substrate
Anti-CRP antibody-coated latex particles
Platform
Automated chemistry analyzer; POC
Turnaround · availability
Routine–STAT · Universal

Human genetic evidence

0.036
Open Targets association (STEMI)

Literature evidence(60)

Showing 40 of 60 linked references.

Clinical trials(8)