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C-reactive protein
Pathway / Plaque inflammation

C-reactive protein

CRPprotein

hs-CRP is a systemic inflammatory marker reflecting plaque-driven inflammation and predicting atherothrombotic events.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleAnchor molecule; acute-phase inflammatory marker in plaque destabilization.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000132693

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
63
A — assay feasibility
96
E — evidence strength
49
T1DI (composite)
12
Specificity differential (R−C)-48
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencymag 2
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduralmag 2
4bstent thrombosismag 2
4cin-stent restenosismag 2
5CABG-relatedmag 2
Coverage: 9/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 24 supporting references. See the discrimination table for all markers.

Assay & specimen

Validated clinical assay
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · Lithium heparin (green-top)
Method / principle
Immunoturbidimetric or immunonephelometric (latex-enhanced for hs)
Reagent / substrate
Anti-CRP antibody-coated latex particles
Platform
Automated chemistry analyzer; POC
Turnaround · availability
Routine–STAT · Universal

Human genetic evidence

0.036
Open Targets association (STEMI)

Literature evidence(60)

Showing 40 of 60 linked references.

Clinical trials(8)