Colony stimulating factor 3 receptor
CSF3RgeneRegulates neutrophil recruitment and inflammatory cell activation in plaque inflammation.
Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleG-CSF receptor; neutrophil mobilization and inflammatory response amplification.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates10
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000119535
Type I vs Type II discrimination
ScoresLow-confidence (proxy)
R — rupture / Type-I28
C — confounder / Type-II52
A — assay feasibility52
E — evidence strength20
T1DI (composite)4
Specificity differential (R−C)-23.3
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.
Assay & specimen
Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable
Human genetic evidence
0.367
Open Targets association (acute_MI)
Literature evidence(0)
No direct literature mentions harvested; included via genetic/target evidence.