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Cystathionine γ-lyase (CSE)
Pathway / Off-pathway / systemic markers

Cystathionine γ-lyase (CSE)

CTHgene

CSE-mediated H₂S generation is a metoprolol target that modulates cardioprotection and vascular remodeling post-MI.

Pathway placement
Cascade stepOff-pathway / systemic markers
Confidencelow
RationaleMetoprolol-regulated; hydrogen-sulfide synthesis enzyme, off atherothrombotic pathway.
Druggability
Not assessed (no mapped human gene target).

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
—
C — non-Type-I
58
A — assay feasibility
52
E — evidence strength
0
T1DI (composite)
0
Specificity differential (R−C)-43.3
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationn/a
2anemia / acute blood lossn/a
2hypovolemia / dehydrationmag 2
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressn/a
3sudden cardiac deathmag 1
4aPCI-related periproceduraln/a
4bstent thrombosisn/a
4cin-stent restenosismag 2
5CABG-relatedn/a
Coverage: 4/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 5 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)