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C-X-C Motif Chemokine Ligand 12
Pathway / Plaque inflammation

C-X-C Motif Chemokine Ligand 12

CXCL12protein

CXCL12 activates endothelial NF-κB signaling, recruits immune cells to atherosclerotic plaques, and mediates platelet–thrombosis interactions.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleNF-κB-mediated endothelial inflammation; platelet-derived mediator; atherosclerotic chemokine axis.
Also acts inPlatelet activation, Endothelial activation/erosion, Systemic / off-pathway
Druggability
DruggableYes
Known drugs / candidates1
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000107562

Type I vs non-Type I discrimination

ScoresNon-Type-I-associated
R — rupture / Type-I
33
C — non-Type-I
56
A — assay feasibility
72
E — evidence strength
75
T1DI (composite)
21
Specificity differential (R−C)-22.3
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
2sepsis / systemic inflammationmag 2
2anemia / acute blood lossn/a
2hypovolemia / dehydrationn/a
2tachyarrhythmian/a
2hypoxemia / respiratory failuremag 2
2hypertensive emergencyn/a
2high-demand / peri-operative stressmag 2
3sudden cardiac deathn/a
4aPCI-related periproceduralmag 1
4bstent thrombosismag 1
4cin-stent restenosismag 2
5CABG-relatedn/a
Coverage: 6/12 axes with evidence
Tier: deep-scored (abstract-extracted) · 17 supporting references. See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(9)