CoronaryAtlas logo
CoronaryAtlas
NADPH oxidase 2
Pathway / Plaque inflammation

NADPH oxidase 2

CYBBgene

NOX2-catalyzed superoxide production oxidizes retained lipoproteins and amplifies inflammatory monocyte/macrophage recruitment in the atherosclerotic plaque.

Pathway placement
Cascade stepPlaque inflammation
Confidencehigh
RationaleOxidative enzyme driving lipoprotein oxidation and leukocyte-mediated vascular inflammation.
Also acts inLipid entry/oxidation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000165168

Type I vs Type II discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
59
C — confounder / Type-II
83
A — assay feasibility
52
E — evidence strength
31
T1DI (composite)
6
Specificity differential (R−C)-24.6
Confounder panel (Type-II drivers)
No confounder evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)