Pathway / Off-pathway / systemic markers

CYP2J2

CYP2J2gene

CYP2J2 generates epoxyeicosatrienoic acids that promote angiogenesis and endothelial recovery post-MI but do not participate directly in atherothrombosis.

Pathway placement

Cascade stepOff-pathway / systemic markers

Confidencelow

RationaleEpoxygenase promoting angiogenesis and endothelial function post-MI; off atherothrombotic axis.

Also acts inEndothelial activation/erosion

Druggability

Not assessed (no mapped human gene target).

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)

Endothelium-specific CYP2J2 overexpression improves cardiac dysfunction by promoting angiogenesis via Jagged1/Notch1 signaling.
Journal of molecular and cellular cardiology · 2018 · PMID 30219518 · doi