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DNASE1
Pathway / Plaque inflammation

DNASE1

DNASE1gene

DNASE1 polymorphisms affecting NET degradation alter neutrophil-mediated plaque inflammation and thrombotic burden in MI.

Pathway placement
Cascade stepPlaque inflammation
Confidencemedium
RationaleNET-clearing enzyme; Q222R variant impairs clearance.
Also acts inPlatelet activation
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableNo
Antibody tractableYes
EnsemblENSG00000213918

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
45
C — non-Type-I
55
A — assay feasibility
52
E — evidence strength
23
T1DI (composite)
5
Specificity differential (R−C)-9.4
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Whole blood — gene is not a circulating analyte; measure protein product or genotype
Collection tube
K2-EDTA whole blood (lavender-top)
Method / principle
SNP genotyping / sequencing; or immunoassay of encoded protein
Reagent / substrate
Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein
Platform
qPCR / NGS / array
Turnaround · availability
Send-out · Genotyping widely available; protein assay variable

Literature evidence(1)