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Drp1
Pathway / Myocardial injury (shared endpoint)

Drp1

DNM1Lprotein

Drp1 (DNM1L) drives mitochondrial fission during cardiomyocyte ischemia and necrosis in acute myocardial infarction.

Pathway placement
Cascade stepMyocardial injury (shared endpoint)
Confidencemedium
RationaleMitochondrial fission protein activated during cardiomyocyte ischemic injury.
Druggability
DruggableYes
Known drugs / candidates0
Small-molecule tractableYes
Antibody tractableYes
EnsemblENSG00000087470

Type I vs non-Type I discrimination

ScoresLow-confidence (proxy)
R — rupture / Type-I
30
C — non-Type-I
76
A — assay feasibility
68
E — evidence strength
30
T1DI (composite)
5
Specificity differential (R−C)-46.1
Non-Type-I axis panel
Does this marker also move in each non-Type-I setting? mag 0–3; higher means less Type-I-specific. n/a = no evidence retrieved, which is not the same as no change.
No non-Type-I axis evidence retrieved.
Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.
Specimen
Serum or plasma
Collection tube
Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)
Method / principle
Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists
Reagent / substrate
Matched anti-target antibody pair (capture + labeled detection)
Platform
ELISA microplate or multiplex (Luminex/MSD)
Turnaround · availability
Send-out / research · Research-grade (no universal clinical assay)

Literature evidence(1)