Drp1

DNM1Lprotein

Drp1 (DNM1L) drives mitochondrial fission during cardiomyocyte ischemia and necrosis in acute myocardial infarction.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleMitochondrial fission protein activated during cardiomyocyte ischemic injury.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000087470

Type I vs Type II discrimination

ScoresLow-confidence (proxy)

R — rupture / Type-I

C — confounder / Type-II

A — assay feasibility

E — evidence strength

T1DI (composite)

Specificity differential (R−C)-56.9

Confounder panel (Type-II drivers)

No confounder evidence retrieved.

Tier: light (literature co-occurrence proxy — lower confidence). See the discrimination table for all markers.

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Serum or plasma

Collection tube

Serum separator (gold/red-top, SST) · K2/K3-EDTA (lavender-top)

Method / principle

Sandwich immunoassay (ELISA) — research-grade unless a cleared assay exists

Reagent / substrate

Matched anti-target antibody pair (capture + labeled detection)

Platform

ELISA microplate or multiplex (Luminex/MSD)

Turnaround · availability

Send-out / research · Research-grade (no universal clinical assay)