DOCK7

DOCK7gene

DOCK7 harbors ANGPTL3 regulatory variants affecting triglyceride-rich lipoprotein levels and plaque lipid burden.

Pathway placement

Cascade stepLipid retention & oxidation

Confidencelow

RationaleANGPTL3 regulatory locus; ANGPTL3 modulates lipoprotein retention and metabolism upstream of atherogenesis.

Druggability

DruggableNo

Known drugs / candidates0

Small-molecule tractableNo

Antibody tractableNo

EnsemblENSG00000116641

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable