EIF2AK3

EIF2AK3gene

EIF2AK3 activation by mitochondrial dysfunction contributes to cardiomyocyte necrosis during myocardial ischemia.

Pathway placement

Cascade stepMyocardial injury (shared endpoint)

Confidencemedium

RationaleEIF2AK3 (HRI/GCN2) mediates mitochondrial stress and unfolded protein response in ischemia.

Druggability

DruggableYes

Known drugs / candidates0

Small-molecule tractableYes

Antibody tractableYes

EnsemblENSG00000172071

Assay & specimen

Class-level default (no specific cleared assay)— generic method inferred from analyte class; confirm against a specific product insert before use.

Specimen

Whole blood — gene is not a circulating analyte; measure protein product or genotype

Collection tube

K2-EDTA whole blood (lavender-top)

Method / principle

SNP genotyping / sequencing; or immunoassay of encoded protein

Reagent / substrate

Allele-specific primers/probes (TaqMan) or NGS panel; or antibody for protein

Platform

qPCR / NGS / array

Turnaround · availability

Send-out · Genotyping widely available; protein assay variable